Acsl4 degradation

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August undefined, 2024

WebMar 18, 2024 · The ACSL4 protein can be recognized by the CMA receptor HSC70 and finally digested in lysosomes. However, abnormalities in the degradation process lead … WebNov 24, 2024 · Peroxisome-dependent and independent initiation of ferroptotic pathways. The peroxidation of PUFAs by ALOXs or POR to produce LOOH is an important step in promoting ferroptosis. The synthesis of ...

Inhibition of autophagy rescues HT22 hippocampal neurons from …

WebACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between … WebApr 14, 2024 · Collectively, these data demonstrated that 20-HETE, a metabolite of AA, enhances ACSL4 degradation by activating the PKC signaling pathway and inducing the expression of E3 ubiquitin ligase FBXO10. frosty factory of america ruston la

CYP1B1 inhibits ferroptosis and induces anti-PD-1 …

WebArachidonic acid induces ACSL4 protein degradation 1659 ACSL4 mRNA half-life determination g protein were incubated with anti-ACSL4 antibody or a control antibody (rabbit IgG) overnight at... WebCombined AA treatment with p115 knockdown suggested an additive role for p115 in AA-driven ACSL4 degradation. Furthermore, in vivo studies revealed a significant upregulation of p115 protein in the liver of mice fed a high fat diet that has been previously reported to induce downregulation of ACSL4 protein expression. This new finding has ... WebMar 14, 2024 · The activated HSPs either support the refolding of misfolded proteins or target them for proteasomal degradation . ... ACSL4 and LPCAT3 enzymes are required for the initiation of ferroptosis. ACSL4 catalyzes the acylation of PUFAs, which are then inserted into membrane PLs via the action of LPCAT enzymes. PUFA-containing membrane PLs … giant beach balls amazon

Proteasomal pathway participates in AA-induced …

ACSL4 promotes hepatocellular carcinoma progression via c

WebFeb 12, 2024 · ACSL4 acyl-CoA synthetase long chain family member 4 Gene ID: 2182, updated on 12-Feb-2024 Gene type: protein coding Also known as: ACS4; FACL4; LACS4; MRX63; MRX68; XLID63 See all available tests in GTR for this gene Go to complete Gene record for ACSL4 Go to Variation Viewer for ACSL4 variants Summary WebMay 27, 2024 · Pretreatment of these cells with ferrostatin-1 (Fer-1), an arylalkylamine that was identified as one of the first chemical inhibitors of ferroptosis, which has been suggested to act by preventing oxidative damage to membrane lipids , blocked ACSL4 degradation completely (Fig. 2a). These data validate the integral role of ACSL4 in ferroptosis ... giant bday cakeWebAug 8, 2024 · The degradation of Nrf2 is mediated by Keap1-dependent ubiquitin-proteasome pathway under quiescent conditions ... ACSL4 forms acyl-CoAs by catalyzing fatty acids and affects the lipid composition . Activation of ACSL4 has been indicated to promote ferroptosis [47, 57]. frosty farmhouse oversized sherpa quilt

"WebIt has been reported that in hepatic cells and primary cortical neurons, ACSL4 is degraded mainly through the proteasome pathway [34,35]. However, as previously hypothesized, the lysosome... " - Acsl4 degradation

Acsl4 degradation

Glia maturation factor-β induces ferroptosis by impairing …

WebMar 17, 2024 · 2.1. Identification of Tubastatin A as a novel ferroptosis inducer. To identify novel small molecule compounds that can induce ferroptosis in cancer cells, we constructed ferroptosis-resistant cell line which ferroptosis driving gene ACSL4 was knocked out in MDA-MB-231 and named MDA-MB-231-ACSL4-KO, and MDA-MB-231-ACSL4-WT was … WebMar 24, 2024 · The transcription factor nuclear factor erythroid-2 (NF-E2)-related factor 2 (Nrf2, encoded by the NFE2L2 gene), which was originally identified as a master regulator of the cellular antioxidant response, is now recognized as a crucial mediator of a wide range of cellular processes (Dodson et al., 2024).Along with its role in mitigating oxidative stress, …

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WebOct 15, 2024 · ACSL4 can exert opposing roles acting as a tumor suppressor or as an oncogene depending on the specific cancer type and tissue environment. Moreover, …

WebApr 1, 2024 · ACSL4 can modulate de novo lipogenesis by accumulating intracellular triglycerides, cholesterols, and lipid droplets in HCC. Mechanistically, ACSL4 … WebHepatic ACSL4 was significantly decreased in both of our NASH models and is also decreased by high-fat diet feeding in mice (36). Interestingly, free arachidonic acid causes ACSL4 to be...

WebOct 30, 2024 · ACSL4 preferentially esterifies polyunsaturated fatty acids such as arachidonic acid. • AA induces ACSL4 degradation via the ubiquitin-proteasome … WebOverexpression of ACSL4 results in a higher rate of arachidonoyl-CoA synthesis, increased 20:4 incorporation into phosphatidylethanolamine, phosphatidylinositol, and triacylglycerol, and reduced cellular levels of unesterified 20:4. Additionally, ACSL4 regulates PGE 2 release from human smooth muscle cells.

WebOct 30, 2024 · Combined AA treatment with p115 knockdown suggested an additive role for p115 in AA-driven ACSL4 degradation. Furthermore, in vivo studies revealed a significant upregulation of p115 protein in the liver of mice fed a high fat diet that has been previously reported to induce downregulation of ACSL4 protein expression. This new finding has ...

WebDec 21, 2024 · Within expectation, a simultaneous degradation of NCOA4 and FTH1 was observed in cisplatin-treated BUMPT cells, which was partially restored by myo-inositol treatment (Figure 3O, lanes 1 and 2). All in all, these in vitro data indicated that myo -inositol down-regulates the expression profile of NOX4 to decelerate ferroptosis in cisplatin ... frosty factory of america incWebArachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation [S] ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for … frosty farmhouse oversized quiltWebThe ACSL4 gene is located on the X-chromosome, with its specific location being Xq22.3-q23. The gene contains 17 exons. [7] ASCL4 encodes a 74.4 kDa protein, FACL4, which … frosty factory of americaWebFeb 12, 2024 · acyl-CoA synthetase long chain family member 4. Gene ID: 2182, updated on 12-Feb-2024. Gene type: protein coding. Also known as: ACS4; FACL4; LACS4; … frosty farmhouse sherpa quiltWebJun 13, 2024 · E Acsl4 mRNA expression levels in Acsl4 shRNA-mediated knockdown PL1 cells and Acsl4-overexpression PG7 cells were determined by qPCR. Data indicated as mean ± S.D. ( n = 3 experiments). frosty farmhouseWebMar 10, 2024 · Indeed, ACSL4 has been shown to be regulated by the balance of its product/substrate ratio where the product of ACSL4, AA-CoA, promotes its degradation through the proteasome pathway in HepG2 hepatocarcinoma cells . Accordingly, 17β-ED treatment significantly extended the ACSL4 protein half-life in breast carcinoma cells by … giant beach wormWebIn our study, erastin reduced the ACSL4 levels in hippocampal HT22 neurons. Comparing HT22 neurons with cancer cell lines, the reduction of ACSL4 levels in erastin-treated HT22 cells should mean consequently an attenuation of ferroptosis. On the contrary, we found in our study that ferroptosis occurred despite reduced ACSL4 levels in HT22 neurons. giant beach mat for wedding