WebMaterial Name: Cisplatin Freeze-Dried Powder for Injection Mouse Oral LD50 4000 mg/kg Molecular Formula: Mannitol. MATERIAL SAFETY DATA SHEET _____ 11. TOXICOLOGICAL INFORMATION Genetic Toxicity: (Study Type, Cell Type/Organism, Result) Carcinogenicity: (Duration, Species, Route, Dose, End Point, Effect(s)) ... WebPatients who have previously experienced Grade I or II platinum hypersensitivity should be pre-medicated prior to carboplatin with: Dexamethasone 20 mg IV in 50 mL NS over 15 minutes (or Hydrocortisone 100mg) 30 minutes prior to carboplatin Chlorphenamine 10 mg IV over 20 minutes

National Center for Biotechnology Information

WebAminoglycoside antibiotics: increased risk of nephrotoxicity and ototoxicity when given within 2 weeks of cisplatin. Diuretics: increased risk of nephrotoxicity and ototoxicity … bitprofit ppt

Cisplatin - NCI - National Cancer Institute

WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has spread to other parts of the body. It is used with other drugs in patients who have already had surgery ... WebSep 10, 2015 · Among patients who received second-line treatment, 28 (70%) were retreated with a rituximab-based regimen with high response rates (82% achieved at least a minor response); 12 patients (30%) were treated with alkylating agents, fludarabine, or bortezomib (67% achieved at least a minor response). Webwith cisplatin some protocols are designed to take advantage of this effect; monitor toxicity closely high dose cyclosporine with oral etoposide. 14. increase in plasma level in etoposide . decrease in clearance of etoposide : etoposide dose should be reduced by 50% with concurrent use of high- bit-publication-east_fa_web.pdf