Ctrp drug sensitivity

Author: pzjq

August undefined, 2024

WebJul 20, 2024 · CTRP V1 quantitatively measured the sensitivity of 242 cell lines to 185 small molecules; CTRP V2 measured the sensitivity of 860 cancer cell lines to 481 small molecules. The molecular data of cell lines in CTRP can be obtained from CCLE. The GDSC collection comprises over 1000 tumor cell lines, ~60% of which are overlapped with CCLE. WebSignificance: We present the largest CCL sensitivity dataset yet available, and an analysis method integrating information from multiple CCLs and multiple small molecules to …

Cancer Therapeutics Response Portal - Broad Institute

WebThe Genomics of Drug Sensitivity in Cancer Project is a collaboration between the Cancer Genome Project at the Wellcome Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is … WebDec 2, 2024 · We investigated the correlation between expressions of drug target versus drug sensitivity covering 222 drugs and 182 drug targets across 985 cell lines. For … simple welding rods for steel

GSCALite: a web server for gene set cancer analysis

WebSep 14, 2024 · To provide a more rigorous assessment of model generalizability between different studies, we use machine learning to analyze five publicly available cell line-based data sets: National Cancer Institute 60, ancer Therapeutics Response Portal (CTRP), Genomics of Drug Sensitivity in Cancer, Cancer Cell Line Encyclopedia and Genentech … WebMar 22, 2024 · Finally, P4HA3-related drugs were searched in CellMiner, Genomics of Drug Sensitivity in Cancer (GDSC), and Cancer Therapeutics Response Portal (CTRP) databases. Results: P4HA3 is significantly overexpressed in most cancers and is associated with poor prognosis. WebThe CTRP drug sensitivity analysis indicated that G6PD and PPAT were significant target genes for multiple anti-cancer drugs, such as zebularine, YM-155, vorinostat, masitinib and etc. (B) The GDSC drug sensitivity analysis indicated that G6PD and PPAT were significant target genes for other important drugs, including vorinostat, ispinesib ... simple welding art

Systematic pan-cancer analysis of the potential tumor diagnosis …

Assessment of modelling strategies for drug response …

WebJun 24, 2024 · The CTRP and GDSC contained data on cytarabine activity. In contrast to AML cells, however, there was no difference in the cytarabine sensitivity between B-ALL and T-ALL cell lines and no... WebJan 17, 2024 · To provide a more rigorous assessment of model generalizability between different studies, we use machine learning to analyze five publicly available cell line-based data sets: National Cancer Institute 60, ancer Therapeutics Response Portal (CTRP), Genomics of Drug Sensitivity in Cancer, Cancer Cell Line Encyclopedia and Genentech … rayleigh number and grashof numberWebFor CTRP v2 data, we evaluated whether small-molecule sensitivity could be correlated with basal gene-expression levels or copy-number variation to identify new … rayleigh number internally heated convection

"WebMay 31, 2024 · EDDY has been used in conjunction with the Cancer Therapeutics Response Portal (CTRP), a dataset with drug-response measurements for more than 400 small molecules, and RNAseq data of cell lines in the Cancer Cell Line Encyclopedia (CCLE) to find potential drug-mediator pairs. " - Ctrp drug sensitivity

Ctrp drug sensitivity

Correlating chemical sensitivity and basal gene expression

WebDec 16, 2024 · In this study, we have considered two expression signature collections: the PS C captures the transcriptional changes induced by a drug; while the SS C captures … WebThe Cancer Therapeutics Response Portal (CTRP) bridges genetic, genealogical, and other cellular characteristics of cancer cell lines with small-molecule sensitivity to support future patient-matched drug discovery based on predictive biomarkers. 36 The Genomics of Drug Sensitivity in Cancer (GDSC) database characterizes 1,000 human cancer cell ...

Did you know?

WebloadNCI60drugSensitivity: Load CTRP data matchStatsWithDrugSetsID: Match identifiers between data and drug sets parseCMapID: Parse CMap identifier … WebSep 2, 2024 · RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma eCollection 2024. Authors

WebAug 8, 2013 · We have quantitatively measured the sensitivity of 242 genomically characterized CCLs to an Informer Set of 354 small molecules that target many nodes in cell circuitry, uncovering protein dependencies that: 1) associate with specific cancer-genomic alterations and 2) can be targeted by small molecules. WebApr 11, 2024 · HIGHLIGHTS. who: (TME et al. from the of Southern California, United Statescombination of the University of California Santa Cruz (UCSC) database, Cancer have published the research: Systematic pan-cancer analysis of the potential tumor diagnosis and prognosis biomarker P4HA3, in the Journal: (JOURNAL) what: The authors evaluated …

WebMay 11, 2024 · 该数据库基于多个研究与数据库信息，整合并重新分析，从细胞、药物和分子三个检索层次，阐述了不同肿瘤细胞对药物的敏感度和反应。 GDSC主要包括三个方面的数据： 1. 药物敏感性基因特征分析；2. 细胞系药物敏感性数据；3. 细胞系的基因组突变与CNV变异数据，表达谱数据以及甲基化数据（GSE68379）;其中，2024年2月的8.2更新 … Web1 day ago · Due to agents with lower AUC values had higher sensitivity, six CTRP derived agents (Fig. 5 C) and five PRISM derived agents (Fig. 5 D) which had higher sensitivity in the RRM2 High and AURKA High group were determined. ... This method has also been extended to predict drug sensitivity to explore the efficacy of biomarker models in agent ...

WebDrug sensitivity (PRISM Repurposing Primary Screen): 99.1th percentile Prediction Accuracy Features of most accurate predictive model Drug sensitivity (PRISM Repurposing Primary Screen) View model details …

WebThe Cancer Therapeutics Response Portal (CTRP) links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity with the goal of accelerating discovery of patient-matched cancer therapeutics. We generated an 'Informer Set' of 481 … In short, BRAF mutation predicted sensitivity to MEK inhibition a finding … rayleigh number in airWebNov 4, 2024 · SLFN11 mRNA expression is commonly associated with chemosensitivity in cancer cell lines. Numbers of genes with expression correlated with sensitivity (R≤-0.2) … simple well acnhWebOct 10, 2024 · Effective computational methods to discover genetic alterations causal to drug sensitivity will improve our understanding of the molecular mechanism of drug … rayleigh number for laminar flowWebIn addition, using the CTRP drug database, we found that sensitivity to austocystin D and erlotinib increased as LMOD1, MAB21L2, and ASPN expression increased ( Figure 5H). … rayleigh number of airWebJan 31, 2024 · Several potential drugs, such as lapatinib, that may target TRPV channel-related genes were identified by mining the genomics of drug sensitivity. Conclusion: This study revealed the genomic changes and clinical characteristics of TRPV channel-related regulatory factors in 33 types of tumors. simple wellbeing tipsWebFeb 27, 2024 · In summary, the multi-target activity of rigosertib, which is controversial, makes this drug an interesting molecule to study in order to deeply understand its mechanism of action and, subsequently, to find the biomarkers that can make rigosertib a profitable drug in the treatment of diseases. ... (CTRP), showing the sensitivity of … simple welding tablehttp://www.ilincs.org/help/signatureLibraries/Cancer-Therapeutics-Response-Signatures simple weight workouts for men