WebStatins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease.They are the most common cholesterol-lowering drugs. Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and … WebJerry R. Colca, Rolf F. Kletzien, in Advances in Pharmacology, 2009 Abstract. Statins, inhibitors of hydroxymethylglutaryl CoA (HMG-CoA) reductase, have been in clinical use for over 20 years. The widespread use of these agents has left doubt of the efficacy of cholesterol-lowering therapy to prevent cardiovascular disease.
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WebIndications. Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, also known as "statins," are used adjunctively to diet and exercise to treat hypercholesterolemia by lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) concentrations while increasing high-density lipoprotein cholesterol (HDL-C) … WebHydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Lovastatin / pharmacology Mice Pravastatin / pharmacology Pyrroles / pharmacology Simvastatin / … how ai change people\u0027s life
The Effect of HMG: CoA Reductase Inhibitors on Cognition
Web4 jul. 2024 · Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, also known as "statins," are used adjunctively to diet and exercise to treat hypercholesterolemia by lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) concentrations while increasing high-density lipoprotein cholesterol (HDL-C) … WebHydroxymethylglutaryl-CoA Reductase Inhibitors* Lovastatin / analogs & derivatives Lovastatin / chemistry Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors … Web28 mrt. 2024 · For example, the HMG-CoA reductase inhibitors lovastatin and cerivastatin diminish the expression of the integrin dimer CD11b (Mac-1, the cognate ligand of ICAM-1 on endothelium and other cells) on monocytes and inhibit adhesion of leukocytes to ECs ( Table ). 26–28 Reduction in adhesion molecule synthesis also applies to other cell types … how ai can help in supply chain