Rab7 effector
WebRab7 is also involved in the maturation of late autophagic vacuoles. Among Rab7 effectors are Rab-interacting lysosome protein (RILP) that controls late endosomal and lysosomal … WebApr 3, 2024 · The Rab7 effector RILP has been shown to directly bind and recruit Vps41 to Rab7/PLEKHM1-positive endosomes (van der Kant et al., 2013; Wijdeven et al., 2016). We …
Rab7 effector
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WebRab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of … WebOct 6, 2016 · A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo proteins …
WebRab7 is also involved in the maturation of late autophagic vacuoles. Among Rab7 effectors are RILP (Rab-interacting lysosome protein) that controls late endosomal and lysosomal transport by mediating the recruitment of dynein/dynactin motors, Rabring7 (Rab7- interacting ring finger protein),(10) and the hVPS34/p150 complex. WebOct 30, 2001 · Rab7 cycles between a GTP bound active and a GDP bound inactive state and between the membrane and the cytosol. The GDP bound form mainly localizes to the …
WebChronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the progression of alcohol liver disease despite elusive mechanisms. More importantly, whether or not hepatoprotective quercetin targets Rab7-associated lipophagy disorder is unknown. … WebRab7 is also necessary for the fusion of lysosomes with autophagosomes to form autolysosomes and enable degradation of the material within the autophagosome. 121 In addition, the transport of autolysosomes along microtubules is promoted by the interaction of Rab7 with its effector FYCO1. 122 Interestingly, it has recently been suggested that ...
WebMar 9, 2024 · Rab7 deficiency exacerbates the severity of acute pancreatitis by impairing the autophagic and endocytic pathways toward lysosomes. High Rab7 expression is …
WebRubicon controls endosome maturation as a Rab7 effector. Sun Q, Westphal W, Wong KN, Tan I, Zhong Q. Proc Natl Acad Sci U S A. 2010 Nov 9. 107(45):19338-43. … glasgow rangers playing tonightWebIn conclusion, we identified the RHD of RILP family members and JIP3/4 as a novel Rab36 binding domain. Although RILP was originally characterized as a Rab7 effector, our … glasgow rangers polo shirtsWebMay 11, 2024 · We show (i) that Mon1-Ccz1 is an effector of Rab5, (ii) that membrane-bound Rab5 is the key factor to directly promote Mon1-Ccz1 dependent Rab7 activation and … glasgow rangers postponed programmesWebOct 2, 2024 · Early-to-late endosome conversion, which is essential for delivery of endosomal cargoes to lysosomes, requires switching of early endosome-specific Rab5 … fx shoulder usWebNov 20, 2024 · Although retromer is known to be a RAB7 effector that depends on this small GTPase for its localization to the endosomal membrane (Seaman et al, 2009; Harrison et … glasgow rangers playing todayWebsecrete numerous effector proteins, including SifA, through a specialized type III secretion system to hijack the host endosomal system and generate the Salmonella-containing … glasgow rangers remaining fixturesWebFeb 15, 2001 · Altogether, these data demonstrate that RILP together with Rab7 plays a fundamental role in the organization of the late endosomal/lysosomal compartment, and … glasgow rangers radio live